Skip to main content

Brett Adams

Profile Picture

Voltage-gated calcium channels, G-proteins, mechanisms of cell signaling, receptors

Associate Professor - Biology Department

Associate Professor

Contact Information

DialPhone: 435 797-7107

Educational Background

PhD, Biological Sciences, University of California, Irvine, 1987
MS, Zoology, Oregon State University, 1982
BS, Zoology, Oregon State University, 1980


B.S. Zoology (with honors), Oregon State University M.S. Zoology, Oregon State University Ph.D. Biological Sciences, UC Irvine

Teaching Interests

Cell Biology, Human Physiology, Cell Signaling

Research Interests

Molecular Mechanisms of Cellular Signaling Pathways


Faculty Member, Neuroscience, Neuronal Signaling Mechanisms

Faculty of 1000 (F1000)

American Heart Association Region III Committee 5A panel review session, 2009

Steinhaus Award for Excellence in Graduate Teaching, 1983

University of California, Irvine

    Publications - Books & Book Chapters

      Book Chapters

    • Adams, B., (2005). Phosphorylation-Dependent Regulation of Voltage-gated Ca2+ Channels. "Chapter 10, In: Voltage-gated Calcium Channels, edited by G. Zamponi. Landes Bio"
    • Adams, B., (1990). Molecular insights into excitation-contraction coupling.. Cold Spring Harbor Symposium *

    * Has not been peer reviewed

    Publications - Fact Sheets

      * Has not been peer reviewed

      Publications - Curriculum

        * Has not been peer reviewed

        Publications - Journal Articles

          Academic Journal

        • Adams, B., (2008). The monomeric G proteins AGS1 and Rhes selectively influence Gi-dependent signaling to modulate N-type (CaV2.2) calcium channels.. American Journal of Physiology: Cell Physiology, 295, C1417-C1426.
        • Adams, B., (2007). Muscarinic modulation of CaV2.3 (R-type) calcium channels is antagonized by RGS3 and RGS3T. American Journal of Physiol: Cell Physiology, 292, C573-C580.
        • Adams, B., (2007). Neurokinin 1 receptors trigger overlapping stimulation and inhibition of CaV2.3 (R-type) calcium channels. Molecular Pharmacology, 71, 284-293.
        • Adams, B., (2004). Differential modulation of CaV2.3 Ca2+ channels by Gaq/11-coupled muscarinic receptors. Molecular Pharmacology, 65, 381-388.
        • Adams, B., (2002). Reconstituted slow muscarinic inhibition of neuronal L-type (CaV1.2c) Ca2+ channels. Biophysical Journal, 83(6), 3256-3267.
        • Adams, B., (2001). RGS2 blocks slow muscarinic inhibition of N-type Ca2+ channels reconstituted in a human cell line. Journal of Physiology, 532.2, 337-347.
        • Adams, B., (2000). Muscarinic stimulation of neuronal a1E Ca channels is selectively blocked by the effector antagonist function of RGS2 and PLCb1. Journal of Neuroscience, 20, 7167-7173.
        • Adams, B., (1999). Biphasic, opposing modulation of cloned neuronal alE Ca channels by distinct signaling pathways coupled to M2 muscarinic acetylcholine receptors. Journal of Neuroscience, 19, 6806-6817.
        • Adams, B., (1999). Regulators of G protein signaling attenuate the G protein-mediated inhibition of N-type Ca channels. Journal of General Physiology, 113, 97-109.
        • Adams, B., (1998). G-protein-dependent facilitation of cloned neuronal alA, alB and alE Ca channels.. Journal of Neuroscience, 18, 5240-5252.
        • Adams, B., (1998). Localization in the II-III loop of the dihydropyridine receptor of a sequence critical for excitation-contraction coupling.. Journal of Biological Chemistry, 273, 24983-2499.
        • Adams, B., (1997). Structural regions of the cardiac Ca channel alC subunit involved in Ca-dependent inactivation.. Journal of General Physiology, 110, 379-389.
        • Adams, B., (1996). Ca2+ current activation rate correlates with a lS subunit expression density.. Biophysical Journal, 71, 156-162.
        • Adams, B., (1994). Critical roles of the S3 segment and the S3-S4 linker of repeat I in activation of L-type calcium channels.. Proceedings of the National Academy of Sciences, USA, 91, 1014-1018.
        • Adams, B., (1994). Heterologous expression of neuronal BI calcium channels in dysgenic skeletal muscle.. Journal of General Physiology, 104, 985-996.
        • Adams, B., (1992). Function of a truncated dihydropyridine receptor as both voltage sensor and calcium channel.. Nature, 360, 169-171.
        • Adams, B., (1991). Contractions of dysgenic skeletal muscle triggered by potentiated, endogenous calcium current.. Journal of General Physiology, 97, 687-696.
        • Adams, B., (1991). Repeat I of the dihydropyridine receptor is critical in determining calcium channel activation kinetics.. Nature, 352, 800-803.
        • Adams, B., (1990). Intramembrane charge movement restored in dysgenic skeletal muscle by injection of dihydropyridine receptor cDNAs.. Nature, 346, 569-572.
        • Adams, B., (1990). Muscular dysgenesis in mice: A model system for studying excitation-contraction coupling.. FASEB Journal, 4, 2809-2816.
        • Adams, B., (1990). Regions of the skeletal muscle dihydropyridine receptor critical for excitation-contraction coupling.. Nature, 346, 567-569.
        • Adams, B., (1989). A novel calcium current in dysgenic skeletal muscle.. Journal of General Physiology, 94, 429-444.
        • Adams, B., (1989). Temperature and synaptic efficacy in frog skeletal muscle.. Journal of Physiology, 408, 443-455.
        • Adams, B., (1989). Temperature effects on membrane chloride conductance and electrical excitability of lizard skeletal muscle fibers.. Journal of Experimental Biology, 144, 551-564.
        • Adams, B., (1987). Thermal dependence of passive electrical properties in lizard muscle fibres.. Journal of Experimental Biology, 133, 169-182.
        • Adams, B., (1986). Physiological consequences of thermoregulation in a tropical lizard (Ameiva festiva). Physiological Ecology, 59, 464-472.

        * Has not been peer reviewed

        Publications - Literary Journal

          * Has not been peer reviewed

          Publications - MultiMedia

            * Has not been peer reviewed

            Publications - Technical Reports

              * Has not been peer reviewed

              Publications - Translations & Transcripts

                Publications - Other

                * Has not been peer reviewed

                Scheduled Teaching

                BIOL 5210 - Cell Biology, Fall 2016

                BIOL 2420 - Human Physiology, Fall 2016

                BIOL 2420 - Human Physiology, Spring 2016

                BIOL 4750, 6750 - Topics in Biology (Topic), Spring 2016

                Graduate Students Mentored

                Roger Bannister, Biology, July 1999 - July 2003