Discovery, synthesis, and mechanism of action of microbial natural products and their derivatives. Main interests are novel antimicrobials (e.g. cyclic lipodepsipeptides, aminoglycosides and pradimicins) and heme-derived metabolites (e.g. biliverdin, mesobiliverdin, and phycocyanobilins). Methods are developed to produce pure and scalable quantities of these compounds to facilitate research and applications in agriculture and medicine.