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Jon Takemoto

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Biology

Professor - Biology Department

Professor

Contact Information

Office Location: BNR 353
DialPhone: 435-797-0671
SendEmail: jon.takemoto@usu.edu


Educational Background

PhD, University of California, Los Angeles, 1973

Teaching Interests

microbiology

Research Interests

Microbiology, biochemistry, and synthetic biology to address current issues in agriculture, medicine and the environment. The focus is on microbial natural products and derivatives with novel antimicrobial and cytoprotective capabilities.

Awards

Teacher Who Made a Difference, 2009

University of Kentucky, College of Education

Graduate Mentor of the Year, 2002

Utah State University

Faculty Honor Lecturer, 1993

Utah State University

Researcher of the Year, 1990

College of Science

Long-Term Research Fellowship, 1988

Japan Society for the Promotion of Science

Alexander von Humboldt Foundation Fellowship, 1981

Federal Republic of Germany

NIH Postdoctoral Fellowship, 1974

Harvard University

Maria Moors Cabot Fellowship, 1973

Harvard University

UCLA Alumni Award, Academic Distinction in Graduate Studies, 1973

UCLA

NIH Predoctoral Fellowship, 1970

UCLA

  • Takemoto, J.Y, (2007). Probing the pore geometry of the syringomycin E channel with polyethylene glycols. Biophys. J. *
  • Takemoto, J.Y, (2005). Saccharomyces cerevisiae mutants with altered levels of the sphingolipid class of M(IP)2Cs display differential sensitivities to the antifungal plant defensin DmAMP1. Yeast *
  • Takemoto, J.Y, (1997). Efficacy of syringomycin E, a new antifungal, in a murine model of vaginal candidiasis. Annual Mtg., Intermountain Branch of the American Society for Microbiology, Abstracts, Vol. 45 *
  • Takemoto, J.Y, (1997). Sterol-dependent pore formation of syringomycin E on red blood cell membranes. Eur. Biophys. J. 26:66 *
  • Takemoto, J.Y, (1997). Syringomycin E, a new antifungal, in a murine model of vaginal candidiasis: efficacy and local toxicity. Abstracts, Ann. Mtg., Amer. Soc. Microbiol. A-041, Miami Beach, FL *
  • Takemoto, J.Y, (1997). Cloning and characterization of SYR4, a novel Saccharomyces cerevisiae gene involved in the response to syringomycin. Intrmtn. Branch, Amer. Soc. for Microbiology, Annual Mtg., Abstracts, Vol. 45, Dugway, Utah. April 26 *
  • Takemoto, J.Y, (1997). Yeast Cell Binding Studies With Radiolabled Syringomycin. Annual Mtg., Intermountain Branch, American Society for Microbiology, Abstracts, Vol. 45. Dugway, Utah, April 26 *
  • Takemoto, J.Y, (1996). CLP-3A, a Novel Antifungal Agent from Pseudomonas Syringae. Abstracts, Annual Mtg., Intermountain Branch, Amer. Soc. Microbiol. 44:A11 (abstract) *
  • Takemoto, J.Y, (1996). Isolation and characterization of novel syringomycin resistant mutants of Saccharomyces cerevisiae. Abstracts, Annual Mtg., Intermountain Branch, Amer. Soc. Microbiol. 44:A13 *
  • Takemoto, J.Y, (1996). Production, purification and in vitro antifimgal activity of syringostatin -A, a new antifungal agent produced by Pseudomonas syringae pv. syringae. Annual Mtg., Intermountain Branch, Amer. Soc. Microbiol. 44:A12 (abstract) *
  • Takemoto, J.Y, (1996). Role of secondary metabolites in biological control by Pseudomonas syringae pv. syringae strains ESC-10 and ESC-11. Abstracts, 8th International Congress of Molecular Plant-Microbe Interactions, Knoxville, TN, July 14-20 (abstract) *
  • Takemoto, J.Y, (1996). The influence of sterol and phospholipid structure on the properties of syringomycin E-induced channels. Biophys. J. 70(2):Al94 (Abstract) *
  • Takemoto, J.Y, (1996). Voltage-gated ion channels formed by syringomycin E in planar lipid bilayers. Biophys. J. 70(2):A194 (Abstract) *
  • Takemoto, J.Y, (1995). A novel bioactive lipodepsipeptide produced by Pseudomonas syringae cherry isolate. Abstracts, Ann. Mtg., Intermountain Branch, Amer. Soc. Microbiol. 43:B8 *
  • Takemoto, J.Y, (1995). Function of syringomycin response gene, SYR2, in yeast sterol metabolism. Abstracts, 95th Ann. Meet. Amer. Soc. Microbiol. A95 *
  • Takemoto, J.Y, (1995). In vitro activity of syringomycin E, a new antifungal produced by Pseudomonas syringae pv. syringae. Abstracts, Ann. Mtg., Intrmntn. Branch Amer. Soc. Microbiol. 43:B10 *
  • Takemoto, J.Y, (1995). In vitro antifungal and fungicidal activity of a cyclic lipodepsipeptide, syringomycin E. Abstracts, 35th Interscience Conf. Antimicrob. Agents and Chemotherapy, F103 *
  • Takemoto, J.Y, (1995). Role of H2O2 in Syringomycin Action Against Yeast. Abstracts, Ann. Mtg., Intrmntn. Branch, Amer. Soc. Microbiol. 43:B9 *
  • Takemoto, J.Y, (1994). Influence of cellular sterol composition on syringomycin inhibition of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Amer. Soc. Microbiol. A95 *
  • Takemoto, J.Y, (1994). Isolation and characterization of novel syringomycin-resistant mutants of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Amer. Soc. Microbiol. A94 *
  • Takemoto, J.Y, (1994). SYR2: A Novel Yeast Gene Involved in the Response to Syringomycin. Abs. Ann. Meet. Amer. Soc. Microbiol. A93 *
  • Takemoto, J.Y, (1993). Antifungal properties of Pseudomonas syringae pv. syringae strain M1 from wheat seed coat. Abstracts, Ann. Mtg., Inter. Branch, Amer. Soc. Microbiol. 41:A4 *
  • Takemoto, J.Y, (1993). Cloning and characterization of SYR2: A novel gene of Saccharomyces cerevisiae involved in the response to syringomycin. Abstracts, Ann. Mtg., Interm. Branch, Amer. Soc. Microbiol. 41:A.5 *
  • Takemoto, J.Y, (1993). Identification of gene, SYR1, involved in syringomycin inhibition of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Interm. Branch, Amer. Soc. Microbiol. 41:A3 *
  • Takemoto, J.Y, (1993). Properties of Syringomycin-Resistant Mutants of Saccharomyces Cerevisiae. Abstracts *
  • Takemoto, J.Y, (1992). Saccharomyces cerevisiae genes involved in the response to Pseudomonas syringae phytotoxin, syringomycin. Phytopathology 82:1126 *
  • Takemoto, J.Y, (1991). Syringomycin-stimulated phosphorylation of the red beet plasma membrane H+-ATPase. Plant Physiol. 96:446 *

Publications - Books & Book Chapters

    Book Chapters

  • Takemoto, J.Y, (2008). Voltage-dependent ion channels induced by cyclic lipodepsipeptides in planar lipid bilayers: structure, properties, and resemblance to native channels. Advances in Planar Lipid Bilayers and Liposomes, 8.
  • Takemoto, J.Y, (2003). The syringomycins: lipodepsipeptide pore formers from plant bacterium, Pseudomonas syringae. Pore Forming Peptides and Protein Toxins
  • Takemoto, J.Y, (2000). Analysis of Phosphoinositides in Protein Trafficking. In, Methods: A Companion to Methods in Enzymology
  • Takemoto, J.Y, (2000). Assay of the Saccharomyces Cerevisiae Dihydrosphingosine C-4 Hydroxylase. Methods in Enzymol. *
  • Takemoto, J.Y, (1992). Bacterial Phytotoxin Syringomycin and Its Action on Host Membranes. IN: Molecular Signals in Plant-Microbe Communications, (ed). D.P.S. Verma. P. 247-260
  • Takemoto, J.Y, (1989). Structure of Syringomycin. A Progress Report. p. 359-361. IN: A. Graniti, R.D. Durbin and A. Ballio (eds.), Phytotoxins and Plant Pathogenesis. Springer-Verlag, Berlin-Heidelberg
  • Takemoto, J.Y, (1989). Syringomycin Effects on Plasma Membrane Ca+2 Transport, p. 167-175. IN: A. Graniti, R. D. Durbin & A. Ballio (eds.), Phytotoxins & Plant Pathogenesis

* Has not been peer reviewed

Publications - Fact Sheets

    * Has not been peer reviewed

    Publications - Curriculum

      * Has not been peer reviewed

      Publications - Journal Articles

        Academic Journal

      • Shrestha, J.P, Baker, C., Kawasaki, Y., Subedi, Y.P, Vincent de Paul, Nzuwah Nziko, , Takemoto, J.Y, Chang, C.T, (2017). Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. European Journal of Medicinal Chemistry, 126, 696-704.
      • Zhang, Q., Alfindee, M.N, Shrestha, J.P, Nziko, Vincent de Paul Nzuwah, , Kawasaki, Y., Peng, X., Takemoto, J.Y, Chang, C.T, (2016). Divergent Synthesis of Three Classes of Antifungal Amphiphilic Kanamycin Derivatives. The Journal of Organic Chemistry, 81:22, 10651-10663.
      • Kawasaki, Y., Nischwitz, C., Grilley, M.M, Jones, J., Brown, J.D, Takemoto, J.Y, (2016). Production and Application of Syringomycin E as an Organic Fungicide Seed Protectant against Pythium Damping-off. Journal of Phytopathology, 164:10, 801–810.
      • Fosso, M., AlFindee, M.N, Zhang, Q., Nziko Vde, P., Kawasaki, Y., Shrestha, S.K, Bearss, J., Gregory, R., Takemoto, J.Y, Chang, C.W, (2015). Structure-activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues. J Org Chem, 80:9, 4398-411.
      • Shrestha, S.K, Grilley, M.M, Anderson, T., Dhiman, C., Oblad, J., Chang, C.T, Sorensen, K.N, Takemoto, J.Y, (2015). In vitro antifungal synergy between amphiphilic aminoglycoside K20 and azoles against Candida species and Cryptococcus neoformans. Med Mycol
      • Napan, K.L, Zhang, S., Anderson, T., Takemoto, J.Y, Zhan, J., (2015). Three enzymes involved in the N-methylation and incorporation of the pradimicin sugar moieties. Biorganic and Medicinal Chemistry Letters, 26:6, 1288-1291. doi: doi.org/10.1016/j.bmcl.2015.01.043
      • Shrestha, S.K, Chang, C.T, Meissner, N., Oblad, J., Shrestha, J.P, Sorensen, K.N, Grilley, M.M, Takemoto, J.Y, (2014). Antifungal amphiphilic aminoglycoside K20: bioactivities and mechanism of action. Frontiers in Microbiology, 5:271, 1-12. doi: doi: 10.3389/fmicb.2014.00671
      • Chang, C.T, Takemoto, J.Y, (2014). Antifungal amphiphilic aminoglycosides. Med. Chem. Comm., 5, 1048-1057.
      • Golo, P., Gardner, D., Grilley, M., Takemoto, J., Krassnoff, S., Pires, M., Fernandes, E., Bittencourt, V., Roberts, D., (2014). Production of destruxins from Metarhizium spp. fungi in artificial medium and in endophytically colonized cowpea plants. PLoS One , 9:8, doi: DOI: 10.1371/journal.pone.0104946
      • Napan, K., Zhang, S., Morgan, W., Anderson, T., Takemoto, J., Zhan, J., (2014). Synergistic Actions of Tailoring Enzymes in Pradimicin Biosynthesis. ChemBioChem, 5:15, 2289–2296.
      • Golo, P.S, Gardner, D., Grilley, M.M, Takemoto, J.Y, Krasnoff, S.B, Pires, M.S, Fernandes, .K, Bittencourt, V.R, Roberts, D.W, (2014). Production of destruxins from Metarhizium spp. fungi in artificial medium and in endophytically colonized cowpea plants.. PloS one, 9:8, e104946.
      • Ito, T., Chen, D., Chang, C.T, Kenmochi, T., Saito, T., Suzuki, S., Takemoto, J.Y, (2013). Mesobiliverdin IXalpha enhances rat pancreatic islet yield and function. Frontiers in Pharmacology, 4:50, doi: DOI10.3389/fphar.2013.00050
      • Shrestha, S., Grilley, M.M, Fosso, M.Y, Chang, C.T, Takemoto, J.Y, (2013). Membrane lipid-modulated mechanism of action and non-cytotoxicity of novel fungicide aminoglycolipid FG08. PLoS One, doi: 8:e73843
      • Shrestha, S., Grilley, M.M, Fosso, M.Y, Chang, C.T, Takemoto, J.Y, (2013). Membrane Lipid-Modulated Mechanism of Action and Non-Cytotoxicity of Novel Fungicide Aminoglycoside FG08. PloS one, 8:9, e73843.
      • Chen, D., Kawasaki, Y., Brown, J., Takemoto, J.Y, (2012). Scalable Bioproduction of Biliverdin IXalpha by Escherichia coli. BMC Biotechnology, 12, 89. doi: DOI:10.1186/1472-6750-12-89
      • Bessonov, A., Takemoto, J.Y, Simmel, F., (2012). Probing DNA - lipid membrane interactions with a lipopeptide nanopore.. ACS Nano, 6:4, 3356-3363.
      • Napan, K.L, Zeng, J., Takemoto, J.Y, Zhan, J., , (2012). A key cytochrome P450 hydroxylase in pradimicin biosynthesis. Bioorganic and Medicinal Chemistry Letters , 22:1, 606-609. doi: doi:10.1016/j.bmcl.2011.10.075
      • Bensaci, M.F, Gurnev, P.A, Bezrukov, S.M, Takemoto, J.Y, (2011). Fungicidal activities and mechanisms of action of Pseudomonas syringae pv. syringae lipodepsipeptide syringopeptins 22A and 25A. Frontiers in Microbiology, 2:216, doi: 10.3389/fmicb.2011.00216
      • Chang, C.T, Fosso, M., Kawasaki, Y., Bensaci, M., Evans, C.K, Wang, J.H, Shrestha, S., Takemoto, J.Y, , (2010). Antibacterial to antifungal conversion of neamine aminoglycoisodes through alkyl modification. Strategy for reviving an old drug into agrofungicides. J. Antibiotics, 63, 667-672.
      • Takemoto, J.Y, (2010). Inhibition of fungi from diseased grape by syringomycin E-rhamnolipid mixture.. Amer. J. Enol. Viti., 61, 120-124.
      • Takemoto, J.Y, (2009). Synthesis and combinational antibacterial study of 5-modified neomycin. J. Antibiotics, 62, 539-544.
      • Takemoto, J.Y, (2008). Bioactive lipopeptides of ice nucleating snow bacterium Pseudomonas syringae strain 31R1. FEMS Microbiol. Lett., 286, 158-165.
      • Takemoto, J.Y, (2008). Altering channel forming activity of syringomycin E via membrane dipole potential. Langmuir, 24, 2987-2991.
      • Takemoto, J.Y, (2007). Sonication-assisted library synthesis of oxazolidine carbohydrate conjugates. J. Combinatorial Chem., 9, 17-19.
      • Takemoto, J.Y, (2007). Syringopeptin SP25A-mediated killing of Gram-positive bacteria and role of teichoic acid D-alanylation. FEMS Microbiol Lett, 268, 106-111.
      • Takemoto, J.Y, (2006). Actin and amphiphilic polymers influence on channel formation by syringomycin E in lipid bilayers. Eur J. Biophys., 35, 382-392.
      • Takemoto, J.Y, (2005). Voltage-dependent synchronization of gating of syringomycin E ion channel. FEBS Letters, 579, 5675-5679.
      • Takemoto, J.Y, (2005). Novel cyclic lipodepsipeptide from Pseudomonas syringae pv. lachrymans strain 508 and syringopeptin antimicrobial activities. Antimicrob. Agents Chemother., 49, 5037-5045.
      • Takemoto, J.Y, (2005). SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis. FEBS Lett., 579, 5675-5679.
      • Takemoto, J.Y, (2005). Sphingolipids influence the sensitivity of lipid bilayers to fungicide syringomycin E.. J. Bioenerg. Biomemb., 37, 339-348.
      • Takemoto, J.Y, (2004). Application of the synthetic aminosugars for glycodiversification: synthesis and antimicrobial studies of pyranmycin.. J. Org. Chem., 69, 1513-1523.
      • Takemoto, J.Y, (2004). Sphingolipid C4 hydroxylation influences properties of yeast detergent-insoluble glycolipid-enriched membranes. FEBS Lett, 569, 272-276.
      • Takemoto, J.Y, (2004). Synthesis of trehalose-based compounds and study of their antibacterial activity against Mycobacterium smegmatis. Bioorg. Med. Chem., 12, 6397-6413.
      • Idkowiak-Baldys, J., Takemoto, J.Y, Grilley, M.M, (2003). Structure– function studies of yeast C-4 sphingolipid long chain base hydroxylase. Biochimica et Biophysica Acta (BBA)/Biomembranes, 1618, 17-24.
      • Takemoto, J.Y, (2003). DmAMP1, an antifungal plant defensin from dahlia (Dahlia merckii), interacts with sphingolipids from Saccharomyces cerevisiae. FEMS Microbiol Letters, 223, 199-203.
      • Takemoto, J.Y, (2003). Effective gating charge of ion channels induced by toxin syringomycin E in lipid bilayers. Bioelectrochem., 5776, 7-Jan.
      • Takemoto, J.Y, (2003). IPT1-independent sphingolipid biosynthesis and yeast inhibition by syringomycin E and plant defensin DmAMP1. FEMS Microbiol. Lett., 11016, 5-Jan.
      • Takemoto, J.Y, (2003). Structure-function studies of yeast C-4 sphingolipid long chain base hydroxylase. Biochim. Biophys. Acta, 1618, 17-24.
      • Takemoto, J.Y, (2002). Syringomycin E channel: a lipidic pore stabilized by lipopeptide. Biophys. J., 82, 1985-1994.
      • Takemoto, J.Y, (2002). Syringotoxin pore formation and inactivation in human red blood cells and model bilayer lipid membranes. Biochim. Biophys. Acta, 1567, 143-149.
      • Takemoto, J.Y, (2002). The synthesis of L-aminosugars and the studies of L-pyranoses on ring III of pyranmycins. Organic Lett., 4, 3997-4000.
      • Takemoto, J.Y, (2001). Spatial charge distribution effects in the conductance of syringomycin E ion channels formed in lipid bilayers. Biological Membranes, 18, 145-153.
      • Takemoto, J.Y, (2000). Effect of temperature on the formation and inactivation of syringomycin pores in red blood cells and bimolecular lipid membranes. Biochim. Biophys. Acta, 1466, 79-86.
      • Takemoto, J.Y, (2000). Kinetics of opening-closure of syringomycin E channels formed in lipid bilayers. Biological Membranes, 17, 653-665.
      • Takemoto, J.Y, (2000). Membrane permeabilizing activities of cyclic lipodepsipeptides, syringopeptin 22A and syringomycin E from Pseudomonas syringae pv. syringae in human red blood cells and in bilayer lipid membranes. Bioelectrochemistry, 52, 161-167.
      • Takemoto, J.Y, (2000). Requirement of sphingolipid alpha hydroxylation for fungicidal action of syringomycin E. FEBS Letters, 478, 26-28.
      • Takemoto, J.Y, (2000). Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very long fatty acids and mannose and phosphoinositol containing head groups. Antimicrob. Agents Chemother., 44, 1174-1180.
      • Grilley, M.M, Takemoto, J.Y, (2000). Assay of the Saccharomyces cerevisiae dihydrosphingosine C-4 hydroxylase.. Methods in enzymology, 311, 9-14.
      • Takemoto, J.Y, (1999). Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. J. Biol. Chem., 274, 34294-34300.
      • Takemoto, J.Y, (1999). Fungal Lethality, Binding, and Cytotoxicity of Syringomycin E. Antimicrob.. Agents Chemo., 43, 371-373.
      • Takemoto, J.Y, (1999). SEC14-dependent secretion in Saccharomyces cerevisiae: non-dependence on sphingolipid-coupled diacylglycerol synthesis. J. Biol. Chem., 274, 12979-1298.
      • Takemoto, J.Y, (1998). Cluster organization of ion channels formed by the antibiotic syringomycin E in bilayer lipid membranes. Biophys. J. 74:2918-2925
      • Takemoto, J.Y, (1998). Cyclic lipodepsinonapeptide producing strains of Pseudomonas syringae pv. syringae: PCR detection and similarity. Appl. Environmental Microbiol. 64:226-230
      • Takemoto, J.Y, (1998). Efficacy of Syringomycin E in a Murine Model of Vaginal Candidiasis. J. Antibiotics 51:743-749
      • Takemoto, J.Y, (1998). Membrane sterol composition modulates the pore forming activity of syringomycin E in human red blood cells. Biochim. Biophys. Acta 1373:163-169
      • Takemoto, J.Y, (1998). Role of ergosterol in growth inhibition of Saccharomyces cerevisiae by syringomycin E. FEMS Microbiol. 167:215-220
      • Takemoto, J.Y, (1998). Syringomycin action gene SYR2 is essential for sphingoplipid 4-hydroxylation in Saccharomyces cerevisiae. J. Biol. Chem. 273:11062-11068
      • Takemoto, J.Y, (1998). Syringomycin E produced by biological control agents controls green mold on lemons. Biological Control 12(2):89-95
      • Grilley, M.M, Stock, S.D, Dickson, R.C, Lester, R.L, Takemoto, J.Y, (1998). Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae.. The Journal of biological chemistry, 273:18, 11062-8.
      • Takemoto, J.Y, (1997). The effect of sterols on the sensitivity of membrane to the channel forming antifungal antibiotic, syringomycin E. Biochim. Biophys. Acta 1324:102-110
      • Takemoto, J.Y, (1996). In vitro antifungal and fungicidal activities and erythrocyte toxicities of cyclic lipodepsinonapeptides produced by Pseudomonas syringae pv.syringae. Antimicrob. Agents Chemother. 40:2710-2713
      • Takemoto, J.Y, (1996). Phytotoxin production by Pseudomonas syringae pv. syringae: syringopeptin production by syr mutants defective in biosynthesis or secretion of syringomycin. FEMS Microbiol. Lett. 138:35-39
      • Takemoto, J.Y, (1996). Properties of voltage-gated ion channels formed by syringomycin E in planar lipid bilayers. J. Membrane Biol. 149:41-47
      • Takemoto, J.Y, (1996). Suppression of mitogen-induced lymphocyte proliferation by syringmycin-E. FEMS Immunol. Med. Microbiol. 15:177-179
      • Takemoto, J.Y, (1996). SYR2, a gene necessary for syringomycin growth inhibition of Saccharomyces cerevisiae. Microbiology 147:477-484
      • Takemoto, J.Y, (1996). Syringopeptins, Pseudomonas syringae pv. syringae phytotoxins, resemble syringomycin in closing stomata. Plant Pathol. 45:564-571
      • Takemoto, J.Y, (1995). Nonpathogenic Pseudomonas syringae wheat isolate M1 produces lipodepsipeptides syringomycin and syringopeptin. FEMS Microbiol. Lett. 131:63-67
      • Takemoto, J.Y, (1995). Other Lipopeptides. Science 267:605
      • Takemoto, J.Y, (1995). Structural Analysis of New Syringopeptins by Tandem Mass Spectroscopy. Biosci. Biotech. Biochem. 59:1374-1376
      • Takemoto, J.Y, (1995). The physiological roles of membrane ergosterol as revealed by the phenotypes of syr1/erg3 null mutant of Saccharomyces cerevisiae. Biosci. Biotech. Biochem. 59:482-486
      • Takemoto, J.Y, (1994). Identification and analysis of the Saccharomycs cerevisae SYR1 gene reveals that ergosterolis is involved in the action of Syringomycin. Microbiology 140:353-359
      • Takemoto, J.Y, (1994). Stereochemical structure of syringomycin, a phytotoxic metabolite of Pseudomonas syringae pv. syringae. Natural Prod. Lett. 4:159-164
      • Takemoto, J.Y, (1993). Protection by sterols against the cytotoxicity of syringomycin in the yeast Saccharomyces cerevisiae. J. Gen. Microbiol. 139:2323-2327
      • Takemoto, J.Y, (1993). Yeast genes involved in growth inhibition by Pseudomonas syringae pv. syringae syringomycin family lipodepsipeptides. FEMS Microbiol. Lett. 114:339-342
      • Takemoto, J.Y, (1992). Structures and stereochemistry of three phytotoxins: syringomycin, syringotoxin and syringostatin produced by Pseudomonas syringae pv. syringae. J. Chem. Soc. Perkin Trans. 1:1149-1157
      • Takemoto, J.Y, (1992). Syringomycin-stimulated phosphorylation of the plasma membrane H+-ATPase from red beet storage tissue. Plant Physiol. 99:1314-1320
      • Takemoto, J.Y, (1991). Mechanism of Action of the Phytotoxin Syringomycin. A resistant mutant of Saccharomyces cerevisiae reveals an involvement of Ca2+ transport. J. Gen. Microbiol. 137:653-659. J. Gen. Microbiol. 136:653-659
      • Takemoto, J.Y, (1990). Structure of phytotoxin syringomycin produced by a sugar cane isolate of Pseudomonas pv. syringae. Tetrahedron Lett. 31:1589-1592
      • Takemoto, J.Y, (1989). 31-P-NMR evidence for cytoplasmic acidification and phosphate extrusion in syringomycin-treated cells of Rhodotorula pilimanae. Biochem. Biophy. Acta 1010:325-329
      • Takemoto, J.Y, (1989). Syringomycin Stimulation of Potassium Efflux by Yeast Cells. Biochim. Biophys. Acta 987:171-173
      • Takemoto, J.Y, (1989). Syringomycin, a Bacterial Phytotoxin, Closes Stomata. Plant Physiol. 90:1435-1439
      • Takemoto, J.Y, (1989). The Structure of Syringomycins A, E and G. FEBS Letter 255:27-31
      • Professional Journal

      • Shrestha, J., Colman, B., Kawasaki, Y., Nziko, V., Subedi, Y., Takemoto, J.Y, Chang, C.T, (2017). Synthesis and Bioactivity Investigation of Quinone-based Dimeric Cationic Triazolium Amphiphiles Selective against Resistant Fungal and Bacterial Pathogens. Eur. J. Med. Chem., 126, 596.
      • Wood, J.L, Miller, C.D, Sims, R.C, Takemoto, J.Y, (2015). Biomass and Phycocyanin Production from Cyanobacteria Dominated Biofilm Reactors Cultured using Oilfield and Natural Gas Extraction Produced Water. Algal Research, 11, 165-168.
      • Zhang, Q., Peng, X., Grilley, M.M, Takemoto, J.Y, Chang, C.T, (2015). Using Fluorogenic Probes for the Investigation of Selective Biomass Degradation by Fungi. Green Chem, 17, 1918-1925.

      * Has not been peer reviewed

      Publications - Literary Journal

        * Has not been peer reviewed

        Publications - MultiMedia

          * Has not been peer reviewed

          Publications - Technical Reports

            * Has not been peer reviewed

            Publications - Translations & Transcripts

              Publications - Other

                Other

              • Takemoto, J.Y, Chen, D., Chang, C.T, Jonathan, W.L, (2015). Therapeutic mesobiliverdin IXalpha compositions and associated methods, Patent assigned, US9119842 B2. United States Patent Office
              • Takemoto, J.Y, Chang, C.W, Shrestha, S.K, Grilley, M.M, (2014). Aminoglycoside and Azole Compositions and Methods. Google Patents
              • Takemoto, J.Y, Chen, D., Chang, C.T, Jonathan, W.L, (2014). Therapeutic compositions and associated methods. World Intellectual Property Organization
              • Takemoto, J.Y, Chen, D., (2013). Biliverdin from Non-Animal Source, U.S. Patent 8,455,222,B2. U.S. Patent and Trademark Office
              • Takemoto, J.Y, (2009). New synthetic antifungal agents. USU Technology Notification/Invention Disclosure *
              • Takemoto, J.Y, (2009). Enhanced bioproduction of biliverdin-IX alpha. Provisional Patent Application 61258126 *
              • Takemoto, J.Y, (2009). Novel antimicrobial aminoglycosides: synthesis and use as antifungals. PCT Utility Patent Application 61258126 *
              • Takemoto, J.Y, (2007). Antimycotic rhamnolipid compositions and related methods of use. U.S.Patent, application serial no. 11/351,572, Feb. 2, 2006 *
              • Takemoto, J.Y, (2007). Method for making fungi compatible artificial snow. U.S. Patent application serial no 20060248793, Nov. 9, 2006 *
              • Takemoto, J.Y, (2006). Bacterial inhibition by natural products produced by pseudomonads. *
              • Takemoto, J.Y, (2004). Antimicrobial activities of lipodepsipeptide syringopeptins. M.S. Thesis, Utah State University, Biology *
              • Takemoto, J.Y, (2004). Studies of Saccharomyces cerevisiae sphingolipid C4 hydroxylation and IPT1 function and their roles in syringomycin E action. Ph.D. Dissertation, Utah State University, Biology *
              • Takemoto, J.Y, (2001). Method of controlling protozoan infections using syringomycin-family lipodepsipeptides. U.S. Patent No. 6,310,037. October 30 *
              • Takemoto, J.Y, (2001). Method of controlling protozoan infections using syringomycin-family lipodepsipeptides. U.S. Patent No. 6,310,037 *
              • Takemoto, J.Y, (1998). Lipodepsipeptides as antifungal and fungicidal agents. U.S. Patent No. 5,830,855 *
              • Takemoto, J.Y, (1997). Discovery, identification, and evaluation of antifungal compounds produced by Pseudomonas syringae. Ph.D. Dissertation. Utah State University, Logan, UT *
              • Takemoto, J.Y, (1996). CLP-C3A, a New Cyclic Lipodepsipeptide from Pseudomonas Syringae. Thesis, Utah State University, Logan, Utah *
              • Takemoto, J.Y, (1992). Red beet Ca-dependent protein kinases and their role in syringomycin action. PhD. Dissertation, USU, Logan, UT. 135 pp *

              * Has not been peer reviewed

              Scheduled Teaching


              Graduate Students Mentored

              Yukie Kawasaki, Biology, May 2008 - June 2016
              Susan Frisby, Biology, September 2012 - June 2014
              Sanjib Shrestha, Biology, August 2008 - January 2014